A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry

One-pot Efficient Oximation-Beckmann Rearrangement of Ketones Catalyzed by Fe3O4 Under Solvent-free Conditions

Fe3O4 nanoparticles were employment as an efficient and magnetically separable Nano catalyst for the synthesis of amides via one-pot Beckmann rearrangement of ketones under solvent-free conditions. Various secondary amides were synthesized by this method in moderate to good yields. The catalyst showed high thermal stability and was recovered and reused at least five times without any considerab...

One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar

 phenytoine derivatives were synthesized , via the  pinacol condensation  with the  reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst  in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yie...

CuCl2 Catalyzed Solvent-free One Pot Synthesis of Dihydropyrimidinones

One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar

phenytoine derivatives were synthesized , via the  pinacol condensation  with the  reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst  in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yiel...

[Et3NH][HSO4] catalyzed one-pot synthesis of 14-aryl-14H-dibenzo[a,j] xanthenes under solvent-free conditions

A simple and environmentally benign procedure for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes by a one-pot condensation of 2-naphthol with aromatic aldehyde in the presence of [Et3NH][HSO4] as an acidic ionic liquid catalyst under solvent-free conditions has been developed. The reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused s...